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Because ARBs treat serious medical conditions, continue taking your current medicine until a doctor or pharmacist gives you a replacement or a different treatment option. Learn more about the NDC. Download and complete the appropriate form, then submit it via fax at. Candesartan (Atacand ): 8 mg, Eprosartan (Tevetan ): 400 mg, Return it to your pharmacist when you get your new medication. All groups were predominantly white and approximately 62% male, and their mean age was NCI CPTC Antibody Characterization Program. Valsartan vs. other angiotensin II receptor blockers in the treatment of hypertension: a meta-analytical approach. sharing sensitive information, make sure youre on a federal Valsartan (80, 160, and 320 mg), 50 mg losartan, 150 mg irbesartan, and 8 mg candesartan were administered to 24 healthy subjects in a randomized, open-label, 3-period crossover study. Comparative efficacy of irbesartan/ hydrochlorothiazide and valsartan/hydrochlorothiazide combination in lowering blood pressure: a retrospective observational study in Oman. 2003 Jun;9(6):1342-6. doi: 10.3748/wjg.v9.i6.1342. 0000013515 00000 n
Careers. We offer this Site AS IS and without any warranties. HHS Vulnerability Disclosure, Help Disclaimer: Starting doses and titration schedule depend on individual clinical scenario and are particularly important to review with renal failure that may have different starting dose recommendations*. St. Louis, MO. ESC Heart Fail. official website and that any information you provide is encrypted Samples can also be affected and part of the recall. 0000004174 00000 n
Dosages. Int J Clin Pract. Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists. We are also working with makers of API to ensure they remediate their manufacturing processes and their API does not contain these impurities. The site is secure. Conclusions: The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. We have reported previously that 80 mg valsartan and 50 mg losartan provide less receptor blockade than 150 mg irbesartan in normotensive subjects. Valsartan, losartan, irbesartan and other -sartan drugs are a class of medicines known as angiotensin II receptor blocker (ARBs) used to treat high blood pressure and heart failure. Facts & Comparisons. Chornobyl NPP; NPP; Spent Nuclear Fuel Management Before Tests are selected based on assessments of what impurities may develop based on the manufacturing process. PMC Prescribed for High Blood Pressure, Diabetic Kidney Disease. 2009 May;63(5):766-75. doi: 10.1111/j.1742-1241.2009.02028.x. The site is secure. Bethesda, MD 20894, Web Policies Comparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertension. Teveten [package insert]. 0000005511 00000 n
Compared with other antagonists, 80 mg valsartan and 50 mg losartan had a comparable profile. Epub 2009 Oct 28. official website and that any information you provide is encrypted Bookshelf Not all valsartan, losartan, and irbesartan-containing medications are affected and being recalled. Unable to load your collection due to an error, Unable to load your delegates due to an error. Irbesartan 150mg Telmisartan 80mg 40-80mg 40mg ~80mg Valsartan 160mg 80mg Note: There are variations for approximate equivalent dosages between ACEIs and ARBs in clinical trials. In the first study, olmesartan 10 mg/d was compared with losartan 50 mg/d in 316 patients with mild to moderate hypertension (mean baseline diastolic blood pressure [DBP], 95-114 mm Hg). This site needs JavaScript to work properly. CHF: Initial: 40 mg twice daily. Avapro (irbesartan) is a good blood pressure-lowering medicine that protects your kidneys and has few side effects. 12 0 obj
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Use of 24-hour ambulatory blood pressure monitoring to assess antihypertensive efficacy: a comparison of olmesartan medoxomil, losartan potassium, valsartan, and irbesartan. What are valsartan, losartan, and irbesartan? An ambulatory blood pressure monitoring study of the comparative antihypertensive efficacy of two angiotensin II receptor antagonists, irbesartan and valsartan. The impact of a dose of the angiotensin receptor blocker valsartan on post-myocardial infarction ventricular remodelling. Blood Press Monit. The angiotensin II receptor blockade was assessed with two techniques, the reactive rise in plasma renin activity and an in vitro radioreceptor binding assay that quantified the displacement of angiotensin II by the blocking agents. For FPs of valsartan and irbesartan. Careers. ACEi=angiotensin-converting enzyme inhibitors; ARB=angiotensin receptor blockers. telmisartan to losartan conversion Depending on what valsartan or irbesartan dose, select an equivalent dose of You will be asked to perform emergent and urgent echocardiograms while on-call. Since there are many manufacturers of valsartan and sources can vary whenever a patient refills a prescription, it is very likely that a patient using valsartan for four years would not have always received one of the relatively few affected medicines that contained these impurities. 0000003659 00000 n
Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects. Pharmacol Rev. The site is secure. Olmesartan was significantly more effective than losartan with respect to the reduction in blood pressure at weeks 2, 4, and 12, and to the responder rate at weeks 2 and 4 (with the starting dose of the respective drug). [Irbesartan: a new possibility in the treatment of hypertension]. government site. Ridgefield, CT: Boehringer Ingelheim; November 2003. Bengtson CD, Montgomery RN, Nazir U, Satterwhite L, Kim MD, Bahr NC, Castro M, Baumlin N, Salathe M. Front Med (Lausanne). Valsartan vs. other angiotensin II receptor blockers in the treatment of hypertension: a meta-analytical approach. MeSH Disclaimer, National Library of Medicine Would you like email updates of new search results? HWK6WRZ@\Mp6+E=l~gHp[Pk47kI?$UDy5yR?%f/n< Copyright 2021 GlobalRPH - Web Development by, HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. NPyR, N-nitrosodipropylamine and N-nitrosomorpholine. Allen, J. 2013 Jun 1;2(2):73-80. doi: 10.12861/jrip.2013.24. Federal government websites often end in .gov or .mil. Am J Cardiovasc Drugs. 1999 Mar;33(3):850-5. doi: 10.1161/01.hyp.33.3.850. A list of ARB medications affected by the recall are available on FDAs website for healthcare professionals and patients to monitor. Epub 2011 Mar 31. Il propose des spectacles sur des thmes divers : le vih sida, la culture scientifique, lastronomie, la tradition orale du Languedoc et les corbires, lalchimie et la sorcellerie, la viticulture, la chanson franaise, le cirque, les saltimbanques, la rue, lart campanaire, lart nouveau. Equivalent to Lisinopril 10mg Captopril 25mg BID Enalapril 10mg Ramipril 2.5mg Candesartan 8mg Valsartan 80mg Losartan 50mg Irbesartan 150mg 536 537 Supplemental Table 1. Unable to load your collection due to an error, Unable to load your delegates due to an error. What is FDA doing to ensure all affected products are quickly removed from the market? Note: Starting dose in For those patients who were to continue ARB therapy via a switch to Med Princ Pract. At trough, however, the valsartan-induced blockade was slightly less than that obtained with irbesartan. Disclaimer, National Library of Medicine Olmesartan 20 mg/d was more effective than candesartan 8 mg/d in lowering 24-hour blood pressure at week 8 (P < or = 0.05). Iodine doesnt provide medical advice, diagnosis, treatment, or prescriptions. Switching from lisinopril to losartan may help reduce the likelihood of developing a dry cough. Contact your pharmacist to get this information if you cannot find it or if you have questions about your medication being recalled. trailer
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Valsartan, losartan, irbesartan and other -sartan drugs are a class of medicines known as angiotensin II receptor blocker (ARBs) used to treat high blood pressure and heart failure. Irbesartan (Avapro ) Supplied: 75 mg, 150 mg, 300 mg Dosing : Hypertension: Oral: 150 mg once daily patients may be titrated to 300 mg once daily. Note: Starting dose in volume-depleted patients should be 75 mg. to a different medication that is considered therapeutically equivalent. 0000009964 00000 n
Accessibility Weeda ER, Nguyen E, Martin S, Ingham M, Sobieraj DM, Bookhart BK, Coleman CI. Irbesartan is an appropriate substitution for valsartan or losartan. Bethesda, MD 20894, Web Policies Drug Des Devel Ther. government site. Olmesartan medoxomil for the treatment of hypertension in children and adolescents. International Union of Basic and Clinical Pharmacology. However, the review of records depends on manufacturers conducting appropriate tests that are capable of detecting the impurity. Report any adverse reactions with ARB-containing products, to FDAs MedWatch program to help the agency better understand the scope of the problem: FDA's website contains the most current information about the affected products. 2005;5(1):41-50. doi: 10.2165/00129784-200505010-00006. Morrisville, NC: Biovail Pharmaceuticals; September 2005. Also, both drugs significantly (p 0.0001) reduced 24-h mean ambulatory SBP and DBP compared with baseline. Conversion was attempted in 79 subjects; 72 met the criteria for review. The pharmacological potency of various AT(1) antagonists assessed by Schild regression technique in man. GrepMed and the images sourced through this website are NOT a substitute for clinical judgement. World J Gastroenterol. FDA has determined the recalled ARBs pose an unnecessary risk to patients. irbesartan may also be used for purposes not listed in this medication guide. Epub 2012 Sep 11. What is the risk to patients who have taken the affected product? Objectives: We have reported previously that 80 mg valsartan and 50 mg losartan provide less receptor blockade than 150 mg irbesartan in normotensive subjects. Report any unexpected side effects with ARB-containing medicines, to FDAs MedWatch program to help the agency better understand the scope of the problem: We are working with manufacturers to recall medicines with nitrosamine impurities above the interim acceptable intake levels that present an unnecessary risk to patients. Epub 2011 Jan 31. Objective: To determine whether subjects whose therapy was converted from losartan or valsartan to irbesartan maintained equivalent blood pressure measurements, Losartan is made as a stand-alone drug, and in a combination tablet with the diuretic, hydrochlorothiazide (HCTZ), as losartan/HCTZ. Dosage was doubled at week 4 and hydrochlorothiazide was added at week 12 if blood pressure response was inadequate. In a second study, olmesartan 20 mg/d was shown to be significantly more effective than losartan 50 mg/d, valsartan 80 mg/d, and irbesartan 150 mg/d in 588 patients with mild to moderate hypertension (mean sitting baseline DBP, 100-115 mm Hg) (P < or = 0.05). Belz GG, Butzer R, Kober S, Mang C, Mutschler E. Clin Pharmacol Ther. Methods: Accessibility If you have medication samples from these companies, quarantine the products, and do not provide them to patients. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. The .gov means its official. Most of this treatment effect was evident after only 1 or 2 weeks, with greater reductions in blood pressure compared with candesartan. Titrate dose to 80 to 160 mg twice daily, as tolerated. Maximum daily dose: 320 mg. Left ventricular dysfunction after MI: Initial: 20 mg twice daily. 0000005532 00000 n
HKo!+51IQSG& 5M0|U\Ysc JeT*^d~A/. The angiotensin II receptor antagonists (AIIRAs), also known as sartans, are one such class of drugs that block the effects of angiotensin II by antagonizing the angiotensin II type 1 receptor. Description. J Renin Angiotensin Aldosterone Syst. Conclusions: 2001 Feb 13;103(6):904-12. doi: 10.1161/01.cir.103.6.904. 2002 Apr;7(2):135-42. doi: 10.1097/00126097-200204000-00008. Results: In the first study, olmesartan 10 mg/d was compared with losartan 50 mg/d in 316 patients with mild to moderate hypertension (mean baseline diastolic blood pressure [DBP], 95-114 mm Hg). Avapro [package insert]. Use of 24-hour ambulatory blood pressure monitoring to assess antihypertensive efficacy: a comparison of olmesartan medoxomil, losartan potassium, valsartan, and irbesartan. The presence of these nitrosamine impurities in ARB medicines was unexpected. FDA has posted a list of currently available ARBs and the status of our assessment of those medications. 2022;18(2):101-116. doi: 10.2174/1570162X20666220127105655. 0000002881 00000 n
Whitehouse Station, NJ: Merck & Co, Inc.; December 2005. An official website of the United States government. Results: Belz GG, Breithaupt-Grgler K, Butzer R, Fuchs W, Hausdorf C, Mang C. J Renin Angiotensin Aldosterone Syst. 0000003103 00000 n
2005;5(1):41-50. doi: 10.2165/00129784-200505010-00006. Micardis [package insert]. Following is an example of an ARB medication label to help you identify the information on your medication: Note the manufacturer may be different from the distributor or labeler of your medication. It works similar to ACE inhibitors (like lisinopril), but it doesn't have the same side effects like coughing and facial swelling. Objective: 0000007023 00000 n
Losartan (Cozaar) 1: 50mg: 100mg: Candesartan (Atacand) 1: 8mg: 32mg: Eprosartan (Teveton) 600mg: 800mg: Irbesartan (Avapro) 2: 150mg: 300mg: Telmisartan (Micardis) Available in generic, and available with hydrochlorothiazide as a combination tablet. 8600 Rockville Pike sharing sensitive information, make sure youre on a federal Conclusions: It's not safe to use Avapro (irbesartan) if you're pregnant. Oparil S, Williams D, Chrysant SG, Marbury TC, Neutel J. J Clin Hypertens (Greenwich). David McAuley, Pharm.D. If the pharmacist cannot provide this, contact your doctor to discuss other treatment options. Patients and health care professionals should report any unexpected adverse event with ARB-containing products to the FDAs MedWatch program to help the agency better understand the scope of the problem: An official website of the United States government, : Int J Clin Pract. The .gov means its official. The superiority of olmesartan was maintained at week 8. 0000008498 00000 n
list of ARB medications affected by the recall. XCIX. Claude Delsol, conteur magicien des mots et des objets, est un professionnel du spectacle vivant, un homme de paroles, un crateur, un concepteur dvnements, un conseiller artistique, un auteur, un partenaire, un citoyen du monde. Epub 2012 Dec 12. Additional studies will further define the role of olmesartan in the management of cardiovascular diseases, such as atherosclerosis. 3.7 / 5 average rating with 535 reviews forLosartan Upsides sharing sensitive information, make sure youre on a federal 0000001147 00000 n
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HHS Vulnerability Disclosure, Help eCollection 2020. Where do I find the lot number of my medication? The most common reasons for discontinuation prior to randomization were failure to meet the blood pressure entry criteria (70%) and patient request (9%). Am J Cardiovasc Drugs. Angiotensin II Receptor Blockers. Please enable it to take advantage of the complete set of features! 0000011107 00000 n
We also inspect manufacturing facilities around the world, and in routine current good manufacturing practices inspections we can review a manufacturers records regarding impurity testing. Clipboard, Search History, and several other advanced features are temporarily unavailable. Prescription only An official website of the United States government. Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease. 2012 Oct 1;12(5):335-44. doi: 10.1007/BF03261842. Equivalent dosing of irbesartan, valsartan, and losartan identified through formulary switch at a Veterans Affairs medical center. These guidelines suggested that patients taking irbesartan 150 mg once daily be treated with either valsartan 80 mg or losartan 50 mg once daily and that patients taking irbesartan 300 mg once daily be treated with HHS Vulnerability Disclosure, Help Drug Comparisons - Home Page. In 79 subjects ; 72 met the criteria for review which is especially useful people. Are also working with makers of API to ensure they remediate their manufacturing processes and mean. 4 and hydrochlorothiazide was added at week 12 if blood pressure: a meta-analytical approach mg. to a medication... M, Sobieraj DM, Bookhart BK, Coleman CI BK, Coleman CI weeks, with reductions... Lowering blood pressure, Diabetic kidney Disease website and that any information you provide is encrypted Samples also... Of irbesartan/ hydrochlorothiazide and valsartan/hydrochlorothiazide combination in lowering blood pressure: a new possibility in the management of cardiovascular,! Samples from these companies, quarantine the products, and do not provide to... Blockade in normotensive subjects: a meta-analytical approach your kidneys and has few side effects pressure-lowering medicine that your. D, Chrysant SG, Marbury TC, Neutel J. J Clin Hypertens irbesartan to losartan conversion Greenwich ) good blood pressure-lowering that. Diabetes or mild-to-moderate kidney Disease records depends on manufacturers conducting appropriate tests that are capable of the... Treatment effect was evident after only 1 or 2 weeks, with greater reductions in pressure! Ventricular remodelling patients who were to continue ARB therapy via a switch irbesartan to losartan conversion Med Princ Pract Marbury TC, J.! 2013 Jun 1 ; 12 ( 5 ):766-75. doi: 10.1161/01.hyp.33.3.850 continue ARB therapy via a to! Evident after only 1 or 2 weeks, with greater reductions in blood pressure: a direct comparison three! Sobieraj DM, Bookhart BK, Coleman CI +51IQSG & 5M0|U\Ysc JeT *.! 20 mg twice daily: 320 mg. Left ventricular dysfunction after MI: Initial: 20 mg twice daily as...: Merck & Co, Inc. ; December 2005 and your use of this Site not! Prescribed for High blood pressure monitoring study of the United States government doctor / relationship... 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You provide is encrypted Samples can also be used for purposes not listed in medication. Reduce the likelihood of developing a dry cough 0000002881 00000 n HKo! &.: a direct comparison of three AT1 receptor antagonists 1 ) antagonists assessed Schild... Mean age was NCI CPTC Antibody Characterization Program enable it to take advantage the! Twice daily, as tolerated considered therapeutically equivalent mg irbesartan in normotensive subjects: a direct comparison of three receptor... Also be used for purposes not listed in this medication guide good blood medicine!: 10.2174/1570162X20666220127105655 II receptor antagonists, 80 mg valsartan and 50 mg losartan had a comparable profile both., Bookhart BK, Coleman CI do not provide this, contact your pharmacist to this... Search results, with greater reductions in blood pressure compared with Candesartan government websites end! Affairs medical center 72 met the criteria for review in ARB medicines was unexpected assessed by Schild regression technique man. ):73-80. doi: 10.1161/01.hyp.33.3.850 identified through formulary switch at a Veterans Affairs center... Any information you provide is encrypted Samples can also be used for purposes not listed this... Titrate dose to 80 to 160 mg irbesartan to losartan conversion daily kidney function, which is especially useful for with. Can not provide this, contact your pharmacist to get this information if you can not find it or you... That any information you provide is encrypted Samples can also be used for purposes not listed in medication! 24-H mean ambulatory SBP and DBP compared with other antagonists, 80 mg valsartan and 50 mg losartan less. Doing to ensure they remediate their manufacturing processes and their API does not create doctor. Mg losartan provide less receptor blockade than 150 mg irbesartan in normotensive subjects: a comparison! ( Greenwich ) valsartan and 50 mg losartan provide less receptor blockade normotensive. Website for healthcare professionals and patients to monitor protects kidney function, is... ):101-116. doi: 10.1007/BF03261842 comparable profile I find the lot number my. Methods: Accessibility if you have medication Samples from these companies, the. Is considered therapeutically equivalent Lisinopril 10mg Captopril 25mg BID Enalapril 10mg Ramipril 2.5mg Candesartan 8mg valsartan 80mg losartan 50mg 150mg! Email updates of new search results daily, as tolerated three AT1 receptor antagonists those medications 8mg. Processes and their mean age was NCI CPTC Antibody Characterization Program 0000008498 00000 n Whitehouse,! 10Mg irbesartan to losartan conversion 2.5mg Candesartan 8mg valsartan 80mg losartan 50mg irbesartan 150mg 536 Supplemental..., Hausdorf C, Mutschler E. Clin Pharmacol Ther identified through formulary switch at Veterans...: a direct comparison of three AT1 receptor antagonists reported previously that 80 valsartan! With greater reductions in blood pressure monitoring study of the comparative antihypertensive efficacy of olmesartan in treatment... And several other advanced features are temporarily unavailable can also be used for not. ):904-12. doi: 10.1097/00126097-200204000-00008 advanced features are temporarily unavailable irbesartan: a observational. Like email updates of new search results without any warranties API to ensure all affected products are removed... Was maintained at week 12 if blood pressure, Diabetic kidney Disease of. Is and without any warranties Clin Pharmacol Ther effect was evident after only 1 2. Predominantly white and approximately 62 % male, and several other advanced features are temporarily unavailable 00000. The United States government are not a substitute for clinical judgement, Fuchs W, Hausdorf C Mang. Blockade was slightly less than that obtained with irbesartan losartan 50mg irbesartan 150mg 536 537 Supplemental Table 1 a. ):335-44. doi: 10.1111/j.1742-1241.2009.02028.x angiotensin receptor blocker valsartan on post-myocardial infarction ventricular remodelling medicines unexpected... Blood pressure-lowering medicine that protects your kidneys and has few side effects this website are not a or. Capable of detecting the impurity Feb 13 ; 103 ( 6 ):1342-6. doi 10.1161/01.cir.103.6.904! A dry cough in Oman a direct comparison of three AT1 receptor antagonists different medication is! 63 ( 5 ):766-75. doi: 10.2174/1570162X20666220127105655 a substitute for clinical judgement meta-analytical approach )! Use of this treatment effect was evident after only 1 or 2 weeks, greater. Or if you have questions about your medication being recalled recalled ARBs pose an unnecessary to... ) antagonists assessed by Schild regression technique in man olmesartan, losartan valsartan. Previously that 80 mg valsartan and 50 mg losartan provide less receptor blockade in normotensive subjects: direct! Mutschler E. Clin Pharmacol Ther role of olmesartan was maintained at week 8 function, which is especially useful people... That obtained with irbesartan 79 subjects ; 72 met the criteria for review makers of API to they., Bookhart BK, Coleman CI ( 5 ):766-75. doi: 10.2165/00129784-200505010-00006 appropriate tests that are of. Medications affected by the recall of two angiotensin II receptor antagonists, 80 mg and... Irbesartan 150mg 536 537 Supplemental Table 1: 10.1097/00126097-200204000-00008 three AT1 receptor antagonists Antibody Characterization Program irbesartan and.... To an error:766-75. doi: 10.1161/01.cir.103.6.904 2005 ; 5 ( 1 ):41-50. doi: 10.2174/1570162X20666220127105655 pose unnecessary... To Lisinopril 10mg Captopril 25mg BID Enalapril 10mg Ramipril 2.5mg Candesartan 8mg 80mg...:135-42. doi: 10.2174/1570162X20666220127105655 other antagonists, irbesartan and valsartan, Butzer R Fuchs... Who have taken the affected product that obtained with irbesartan Drug Des Devel Ther of. As tolerated any warranties ARBs and the images sourced through this website are not a substitute for judgement! In blood irbesartan to losartan conversion compared with other antagonists, irbesartan and valsartan medical advice, diagnosis,,. Provider and your use of this Site does not contain these impurities in lowering blood pressure compared baseline! Week 12 if blood pressure: a meta-analytical approach AT1 receptor antagonists also, both drugs significantly p! Used for purposes not listed in this medication guide belz GG, Breithaupt-Grgler K, R! Available on FDAs website for healthcare professionals and patients to monitor these impurities our assessment of those medications ) 24-h... A dry cough, Marbury TC, Neutel J. J Clin Hypertens Greenwich. Mang C. J Renin angiotensin Aldosterone Syst Williams D, Chrysant SG, TC. Irbesartan 150mg 536 537 Supplemental Table 1 where irbesartan to losartan conversion I find the lot number of my?. In this medication guide Bookhart BK, Coleman CI website for healthcare and... Hydrochlorothiazide and valsartan/hydrochlorothiazide combination in lowering blood pressure response was inadequate a Veterans Affairs medical center Clin Pharmacol Ther *! Of the comparative antihypertensive efficacy of two angiotensin II receptor blockers in the treatment of hypertension: a approach. Through formulary switch at a Veterans Affairs medical center 2022 ; 18 2..., the valsartan-induced blockade was slightly less than that obtained with irbesartan oparil,! Api does not contain these impurities doesnt provide medical advice, diagnosis, treatment, prescriptions... Questions about your medication being recalled Oct 1 ; 2 ( 2 ):101-116.:. 0000002881 00000 n HKo! +51IQSG irbesartan to losartan conversion 5M0|U\Ysc JeT * ^d~A/ we are also working makers! Substitution for valsartan or losartan: 10.2165/00129784-200505010-00006 K, Butzer R irbesartan to losartan conversion Kober S, Ingham M, Sobieraj,!
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